Аннотация
Крысы, содержащиеся на высокожировой/высокосахарозной диете (ВЖСД) в течение 10-12 недель, демонстрировали развитие гипергликемии и признаки висцерального ожирения. Субэпикардиальные миоциты левого желудочка (ЛЖ) сердец этих крыс отличались от контроля существенно увеличенной фракцией внеклеточных потенциалов действия (вПД) сердца, характеризующихся выраженной фазой следовой гиперполяризации (СГ) и ускоренным спадом вПД. Локальная доставка в зону регистрации вПД апамина (блокатора Са2+-зависимых К+-каналов низкой проводимости (IKCa, SK-каналы) в концентрации 500 нМ в составе раствора внутри пипетки сопровождалась подавлением фазы СГ и продлением спада вПД. Полученные данные предполагают, что потребление ВЖСД ведет к увеличению экспрессии и/или активности SK-каналов и, как результат, к развитию СГ и укорочению вПД эпикардиальных кардиомиоцитов ЛЖ сердца крыс.
Литература
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