Аннотация
Роль Ca2+-активируемых калиевых каналов низкой проводимости (SK) в патогенезе кардиомиопатий различной этиологии остается малоизученной. Целью данной работы было оценить влияние блокатора этих каналов апамина на электрогенез внеклеточно регистрируемых потенциалов действия (вПД) субэпикардиальных миоцитов левого желудочка изолированных сердец ложнооперированных крыс и крыс с инфарктом миокарда, вызванным ишемией-реперфузией. Было установлено, что локальная доставка в зону регистрации вПД блокатора SK-каналов апамина в концентрации 500 нМ не влияла на профили вПД в группе ложнооперированных крыс, но вызывала существенное замедление времени реполяризации и снижение фазы следовой гиперполяризации вПД в группе крыс с инфарктом миокарда. Полученные данные предполагают о том, что указанные изменения в электрогенезе вПД после инфаркта могут быть связаны с усилением экспрессии и/или активности SK-каналов в субэпикардиальных миоцитах. Обсуждается возможная роль этих каналов в структурно-функциональном ремоделировании миокарда левого желудочка сердца после ишемии-реперфузии.
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