Аннотация
При помощи микроэлектродного метода изучены реакции пептидергических нейронов VD1 и RPaD2 в составе изолированной ЦНС Lymnaea stagnalis в ответ на пролонгированное (не менее 2 ч) действие высоких концентраций D-глюкозы (10 мМ). Установлено, что электрические характеристики мембраны RPaD2, по сравнению с VD1, претерпевают существенные изменения в условиях гипергликемии – снижение сопротивления мембраны (Rm) на фоне возрастания её ёмкости (Cm) и постоянной времени (τm). Несмотря на неизменность частотных характеристик данной пары нейронов, отмечается деполяризация мембраны VD1, в то время как изменения потенциала покоя для RPaD2 не носят статистически достоверного характера. Изменения временны́х, но не амплитудных характеристик потенциала действия VD1 и RPaD2 носят схожий характер, выражающийся в увеличении длительности основных его фаз (де- и реполяризации, следовой гиперполяризации). Предполагается, что «унификация» электрических свойств мембраны нейросекреторных (VD1/RPaD2) нейронов ЦНС Lymnaea в условиях гипергликемии, является адаптацией, направленной на преодоление возможной десинхронизации спайковой активности этих клеток как результат ослабления, инициированного высоким содержанием глюкозы в интерстиции, электрического сопряжения между ними.
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