Аннотация
На новорожденных крысятах 3–16-дневного возраста (Р3–16) изучено влияние Ni2+, блокатора низкопороговых кальциевых каналов Т-типа (T-VDCC) и натрий-кальциевого обменника (NCX), на параметры сердечного и дыхательного ритмов. Обнаружена четкая возрастная зависимость выраженности аритмогенного эффекта, возникающего при блокаде кальциевых каналов. У 100% 3-дневных крысят при инъекции NiCl2 в дозе 109 мг/кг (ED100) возникает преходящий атипичный сердечный ритм, представляющий собой чередование периодов умеренной брадикардии с патологически медленным (до 20–60 сокр/мин) сердечным ритмом. Параллельно развивается выраженная дисфункция дыхательной системы с пачечной формой дыхания. Данный симптомокомплекс возникает у 75% 10–14-суточных крысят и полностью отсутствует у 15–16-суточных. Феноменологически сходные нарушения сердечного ритма наблюдаются у новорожденных крысят после инъекции хлорида никеля, при отравлении ингибиторами ацетилхолинэстеразы и при активации центральных Н-холинергических структур. Полученные данные позволяют предполагать, что в ранний период постнатального онтогенеза крыс нарушение механизмов кальциевого обмена может играть определенную роль в развитии нарушений ритмогенеза.
Литература
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