Аннотация
Исследованы особенности распределения различных фотосенсибилизаторов (ФС) (радахлорина, бенгальского розового и копропорфирина) в клетках инфузорий Paramecium caudatum и лобозных амеб Amoeba proteus. Характер аккумуляции фотосенсибилизаторов оценивали по результатам как прижизненных наблюдений, так и на фиксированном материале, с использованием методов флуоресцентной и конфокальной сканирующей лазерной микроскопии. Показано, что исследованные одноклеточные эукариотные организмы имеют сходное с млекопитающими внутриклеточное распределение ФС и могут быть использованы в качестве модельных объектов на первых этапах доклинических исследований веществ – потенциальных ФС. Предложены некоторые методические рекомендации по выявлению клеточных компартментов, в которых происходит избирательное накопление ФС.
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