Аннотация
Данное исследование направлено на анализ роли ионов кальция в механизме преобразования светового сигнала в сетчатке большого прудовика Lymnaea stagnalis. С этой целью изучено влияние на электрические реакции изолированного глаза моллюска веществ, влияющих на концентрацию цитоплазматического Сa2+. Применяли: модулятор кальциевого тока 2-аминоэтил дифенил борат, хелатирующий агент двухвалентных катионов EGTA, а также (+)-цис-дилтиазем и Cd2+ как блокаторы кальциевых каналов. Все применявшиеся вещества с различной степенью эффективности подавляли медленную волну электроретинограммы и связанную с ней импульсную активность. Делается вывод, что фототрансдукция в микровиллярных рецепторах сетчатки прудовика включает повышение концентрации цитоплазматического Ca2+. Результаты фармакологических экспериментов, а также особенности ультраструктуры сетчатки моллюска позволяют предполагать, что этот результат достигается не только выбросом Ca2+ из внутриклеточных депо апикальных частей фоторецепторов, но и, по крайней мере, частично поступлением из внеклеточной среды.
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