Аннотация
Настоящая работа посвящена исследованию влияний умеренного неонатального болевого стресса, вызванного у новорожденных самцов и самок крысят созданием очага воспалительной боли, на стрессовую реактивность гормонального ответа и когнитивные процессы в водном лабиринте Морриса во взрослом состоянии. Полученные данные указывают на отсутствие значимых различий в показателях пространственного обучения и памяти между подопытными крысами, подвергнутыми неонатальной воспалительной боли, и контрольными животными. Однако у подопытных крыс обнаружены половые различия в пространственной долговременной памяти, эффективность которой была выше у самцов, чем у самок. После тестирования долговременной памяти, реактивность гипоталамо-гипофизарно-адренокортикальной системы, оцененная по содержанию гормона стресса кортикостерона в плазме крови в ответ на формалиновый тест, у подопытных самцов была выше, чем у самок. Только у подопытных самок обнаружены различия между показателями кратковременной и долговременной памяти, с более высокой эффективностью кратковременной памяти. Таким образом, обнаружен половой диморфизм во влиянии неонатального болевого стресса на пространственную долговременную память у взрослых крыс; у подопытных самцов по сравнению с подопытными самками выявлена более эффективная долговременная память, сочетающаяся с более высокой стрессовой реактивностью гормонального ответа.
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