Аннотация
Известно, что стресс-индуцибельный белок теплового шока 70 кДа (Heat shock protein 70, Hsp70) способен оказывать защитный эффект при эндотоксемии и сепсисе благодаря способности взаимодействовать с рецепторами иммунокомпетентных клеток и модулировать иммунный ответ. Однако остается не известным, способен ли Hsp70 ослабить лихорадочную реакцию, характерную для эндотоксемии. Нами было выполнено сравнительно-физиологическое исследование, в ходе которого у голубей и крыс с предварительно вживленными электродами и термисторами для регистрации показателей терморегуляции (температуры мозга, периферической вазомоторной реакции, сократительной активности мышц) были изучены эффекты профилактического введения рекомбинантного Hsp70 человека (HSPA1A) при эндотоксемии, вызванной введением липополисахарида (ЛПС), а также проанализировано изменение числа лейкоцитов у крыс в тех же условиях. Установлено, что профилактическое введение Hsp70 уменьшает величину ЛПС-индуцированного лихорадочного ответа у голубей и крыс и ускоряет нормализацию числа лейкоцитов в крови у крыс. Полученные данные свидетельствуют об универсальности физиологических механизмов реализации защитных свойств Hsp70 у данных представителей теплокровных животных.
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