Аннотация
Исследовали влияние воспалительной боли у новорожденных крысят на динамику содержания кортикостерона в плазме крови, а в поздний препубертатный период развития (45-53 дня) − на процессы пространственного обучения, кратковременной и долговременной памяти и реактивность гипоталамо-гипофизарно-адренокортикальной системы (ГГАКС) к стрессу принудительного плавания у крыс обоего пола. Впервые обнаружено продолжительное усиление реактивности ГГАКС в ответ на периферический очаг воспалительной боли, вызванный периферической инъекцией формалина, у новорожденных крысят, что дало возможность предполагать о модификации в развитии ГГАКС и возможном ее участии в регуляции когнитивных способностей. Обнаружено, что неонатальная боль вызывала дефицит пространственного обучения и памяти, проявив половой диморфизм в реализации процессов пространственного обучения и памяти. После регистрации долговременной памяти у 53-дневных крыс в ответ на принудительное плавание обнаружено повышенное содержание кортикостерона по сравнению с базальным уровнем, но различий в уровне гормона между крысами с неонатальной болью и контрольными животными, как и половых различий, не было выявлено. Таким образом, у крыс в поздний препубертатный период развития не обнаружено прямой взаимосвязи между активацией ГГАКС неонатальной болью и показателями пространственного обучения и памяти, что, вероятно, указывает на вовлечение других нейробиологических систем на влияние неонатальной боли на когнитивные способности.
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