Abstract
In two models of acute poisoning of rats with paraoxon (POX) upon specific and nonspecific inhibition of carboxyl esterase (CE) activity of blood plasma, the effect of POX on the morphology and functions of the kidneys of rats was estimated within a period from 1 day to 6 weeks after the poisoning. During the first 3 days after the poisoning, development of transient glycosuria, increased excretion of Calbindin and sulfated glycosaminoglycans (GAGs) were revealed in the urine of rats. One day after the poisoning, a positive reaction (AFOG+) was observed in the descending and ascending limbs of loop of Henle and collecting tubules of rats upon the non-specific inhibition of CE. After 2 weeks, in the rats of this group the AFOG+ reaction was registered in the proximal tubules, together with desquamation of epithelial cells. Morphometric studies of individual elements of the nephron of rat kidneys indicate changes in the size characteristics of the renal corpuscle and the tuft of capillaries of Bowman capsule 3 days and then 2 weeks after the poisoning, regardless of the mode of CE inhibition. In 3 days after the poisoning and in all subsequent periods, intoxicated rats showed a change in the luminal diameter of the proximal tubules and the area of the lumen of the collecting tubules. The most pronounced differences in the luminal diameter of the distal tubules were seen in 3 days, 4 and 6 weeks after the poisoning.