ВЛИЯНИЕ ФНО-α, ИЛ-2, ИЛ-5, ИЛ-6 НА СОКРАЩЕНИЯ МЫШЦ ТРАХЕИ И БРОНХОВ КРЫСЫ
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Ключевые слова

цитокины
сенсибилизация овальбумином
гладкая мускулатура трахеи и бронхов

Как цитировать

Блажевич, Л. Е., Смирнова, О. Е., Кирилина, В. М., & Кривченко, А. И. (2021). ВЛИЯНИЕ ФНО-α, ИЛ-2, ИЛ-5, ИЛ-6 НА СОКРАЩЕНИЯ МЫШЦ ТРАХЕИ И БРОНХОВ КРЫСЫ. Российский физиологический журнал им. И. М. Сеченова, 107(8), 1027–1038. https://doi.org/10.31857/S0869813921080021

Аннотация

В статье рассмотрена роль ФНО-α, ИЛ-2, ИЛ-5, ИЛ-6 в сократительной активности гладкой мускулатуры трахеи и бронхов крысы. Исследования проводились на изолированных препаратах с применением электрической стимуляции постганглионарных нервов (частота - 30 стим./с, длительность – 0.5 мс, амплитуда - 20 В, продолжительность стимуляции - 10 с). Были сформированы две группы животных: контрольная (получала внутрибрюшинную инъекцию физиологического раствора) и экспериментальная с сенсибилизацией овальбумином (получала внутрибрюшинную инъекцию овальбумина с его повторным введением через 14 дней). Далее проводилась оценка сокращения мышцы трахеи и бронхов после повторного введения овальбумина и после перфузии растворами интерлейкинов. В результате исследования выяснено, что ФНО-α, ИЛ-2, ИЛ-5, ИЛ-6 приводят к выраженному увеличению сократительных ответов гладкой мышцы трахеи и бронхов как в контрольной группе, так и в группе животных, сенсибилизированных овальбумином. Наибольшее констрикторное влияние на мышцу среди исследованных цитокинов принадлежит ФНО-α и ИЛ-6.

https://doi.org/10.31857/S0869813921080021
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