КАНАЛ TRPC6 В ПОДОЦИТАХ ПОЧЕЧНЫХ ГЛОМЕРУЛ
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Ключевые слова

почка
гломерула
подоцит
фокально-сегментарный гломерулосклероз
каналы TRPC
Ca2 - сигнализация

Как цитировать

Михайлова, В. Б., Карпушев, А. В., & Юдина, Ю. С. (2021). КАНАЛ TRPC6 В ПОДОЦИТАХ ПОЧЕЧНЫХ ГЛОМЕРУЛ. Российский физиологический журнал им. И. М. Сеченова, 107(2), 135–153. https://doi.org/10.31857/S0869813921020035

Аннотация

Важнейшим компонентом фильтрационного аппарата почечных гломерул являются специализированные клетки висцерального эпителия – подоциты. Физиологическая функция подоцитов критически зависит от надлежащей регуляции внутриклеточного содержания Ca2+; избыточный вход Ca2+ в клетки может привести к нарушению морфологии клеток, подоцитопатии, апоптозу и последующему повреждению гломерулы в целом. Подоцитопатия является одной из основных характеристик протеинурии и фокально-сегментарного гломерулосклероза. Одним из ключевых белков, ответственных за вход Ca2+ в подоцитах, является ионный канал TRPC6. С момента первого обнаружения мутации в гене, кодирующем TRPC6, внимание научного сообщества сосредоточено на исследовании роли этого ионного канала в возникновении и развитии заболеваний почек. Как усиление, так и снижение функциональной активности TRPC6 сопряжено с проявлением тяжелых нефротических синдромов, ведущих к терминальной стадии хронической болезни почек. В обзоре приведены материалы, касающиеся регуляции активности TRPC6 и роли этого канала в патогенезе гломерулярных заболеваний.

https://doi.org/10.31857/S0869813921020035
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