НОВЫЕ ДОСТИЖЕНИЯ В ИЗУЧЕНИИ ЭНДОГЕННЫХ РЕГУЛЯТОРОВ СИНТЕЗА И СЕКРЕЦИИ ГОНАДОТРОПИНОВ
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Ключевые слова

гонадотропин, гипоталамо-гипофизарно-гонадная ось, гонадотропин-ингибирующий гормон, активин, ингибин, лептин, адипонектин

Как цитировать

Деркач, К. В., & Шпаков, А. О. (2018). НОВЫЕ ДОСТИЖЕНИЯ В ИЗУЧЕНИИ ЭНДОГЕННЫХ РЕГУЛЯТОРОВ СИНТЕЗА И СЕКРЕЦИИ ГОНАДОТРОПИНОВ. Российский физиологический журнал им. И. М. Сеченова, 104(12), 1409—1427. https://doi.org/10.1134/S0869813918120038

Аннотация

Гонадотропины — лютеинизирующий (ЛГ) и фолликулостимулирующий гормоны (ФСГ) — являются ключевыми регуляторами гипоталаламо-гипофизарно-гонадной оси. Их синтез и секреция контролируются гонадолиберином, гипоталамическим рилизинг-фактором. Однако в последние годы все большее внимание приковано к другим регуляторам продукции гонадотропинов — гонадотропин-ингибирующему гормону, активинам, ингибинам, фоллистатину. Наряду с этим показано, что синтез и секреция гонадотропинов могут контролироваться адипокинами — лептином и его функциональным антагонистом адипонектином, которые осуществляют тесную взаимосвязь между энергетическим балансом и функциональным состоянием репродуктивной системы. Адипокины регулируют продукцию гонадотропинов как через гипоталамические механизмы, так и непосредственно воздействуя на гонадотрофы гипофиза. В обзоре рассмотрены современные достижения в области изучения регуляторного влияния и механизмов действия гонадотропин-ингибирующего гормона, активинов, ингибинов, фоллистатина, лептина и адипонектина на продукцию гонадотропинов и зависимые от них репродуктивные функции.

https://doi.org/10.1134/S0869813918120038
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